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Furthermore, GRP78 binds to unfolded proteins to activate three signaling proteins, namely PERK, ATF6, and IRE1, which are responsible for ERs and signaling transmission

Since B12 is required for both the methionine synthase reaction and the methylmalonyl-CoA mutase reaction a megaloblastic anemia resulting from B12 deficiency is also associated with an accompanying methylmalonic acidemia, whereas megaloblastic anemias caused by folate deficiency are not

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If slight bleeding occurs, apply gentle pressure with a clean cotton ball or gauze pad

doi: 10.7554/eLife.02523 78 ChenDFanZRauhMBuchfelderMEyupogluIYSavaskanN