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In studies of human glioblastoma, the absence of exogenous Gln significantly reduces glutamate levels, resulting in the conversion of the dimer GLS1 into a self-assembled, extremely low Km filamentous polymer that further depletes intracellular Gln

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[DOI] [PubMed] [Google Scholar] 73.Riederer P., Sofic E., Rausch W.D., Schmidt B., Reynolds G.P., Jellinger K., Youdim M.B

Ying et al., 2024)