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Anitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice

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For chronic weight management, the same starting dose and titration schedule apply

The earlier marketed amylin-class agent, pramlintide, is a triple-proline-substituted analog engineered specifically to reduce fibrillation, but it retains a short duration of action

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At greater than or equal to 4 times the human clinical exposure based on AUC in patients with ITP at 75 mg/day and 2 times the human clinical exposure based on AUC in patients with chronic hepatitis C at 100 mg/day, cataracts were observed in mice after 13 weeks and in rats after 39 weeks of dosing [see Warnings and Precautions (5.5)]