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Nicotine dependence is a specific form of substance use disorder recognized in medical literature

In recent years, the effect of smoking on microbiome of lower respiratory tract attracted increasing attention

Psychiatry Suppl

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Curly: Thin tobacco circles you get when you cut a navy plug, twist or roll cake

it is a systemic antagonist that modifies microcirculation, disrupts the finely tuned immune response, and shifts the ecological balance of the oral microbiome into a more hostile state