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Dineley KE, Votyakova TV, Reynolds IJ

F.et al (2024)

The primary treatment consists in regular injections of growth hormone, but because of needle pain and the considerable expense, researchers began to look for other ways to boost the levels of growth hormone in these children

& Gabrilovich, D

Eskes hypothesized that hyperhomocysteinemia, even with normal folate levels, could be a toxic agent for the developing embryo (60)

Technological progress, widespread exposure to artificial lighting in the evening and nighttime hours with low exposure to sunlight during the day, lack of physical activity, prolonged mental activity during the day and often also in the period immediately preceding going to sleep, irregular meal times, shift work and/or irregular work rhythms cause circadian rhythm sleep-wake disorders manifested, among other things, by poor sleep quality and decreased psychophysical performance during the day, to be common health problems in developed countries