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IGF-1 LR3 as a Probe: IGF-1 LR3 is employed in research to assess whether enhanced IGF-1type signaling can mitigate some of these catabolic signatures in specific models, providing insight into the crosstalk between glucocorticoid pathways and anabolic/repair pathways
This approach is mainly indicated for lesions involving less than 90 of the bowel circumference and 3 cm in length (with double discoid excision feasible for larger lesions ~5 cm), aiming to reduce morbidity compared to segmental resection while maintaining similar recurrence rates
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However, few studies targeted the frailty biomarkers were found
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