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Breast tumors promote substance P secretion by adjacent sensory neurons, leading to cell death of a small proportion of the tumor cells, subsequent single-stranded RNA release, TLR7-mediated signaling, and metastasis of the surviving tumor cells [250]

Taken together, we propose that metabolic remodeling during cold acclimation primarily enhances spare respiratory capacity, ensuring sufficient energy availability when demand arises under low-temperature conditions

Embracing proteostasis resilience as a central organizing principle provides both a conceptual lens and a translational strategy, guiding the development of next-generation interventions capable of restoring or strategically modulating equilibrium across diverse and complex disease states

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