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DSIP has been studied for various potential physiological roles, including: Stress response and adaptation Pain modulation Immune system regulation Antioxidant properties Effects on endocrine function DSIP has been investigated for potential applications in sleep disorders, pain management, and substance withdrawal syndromes

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In addition, individual differences in the physiological requirements for testosterone often make it difficult for exogenous supplementation to meet the needs of individual patients [16]

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Firstly, CD206 was employed as the M2 macrophage marker to confirm macrophage polarization status using immunofluorescence staining performed under inflammatory stimuli (LPS and IFN-)