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Structurally, CHAC2 typically forms a dimer

Preserved in its most bioavailable reduced form in a non-soy base

However, the rational to eliminate senescent cells remains evident, with the necessity to develop specific therapies in a context of diseases and tissues

This was confirmed in 2020 by the TOMATO study, in which the authors described the C/D ratio as a predictor of death-censored graft survival (158)

Neurons showed reduced cell surface area, elevated lipid peroxidation, and characteristic features of ferroptosis

In light of the pivotal role of macrophages and ROS in the pathogenesis of atherosclerosis, strategies to scavenge ROS within plaque-associated macrophages are considered promising for atherosclerotic therapy 16,17,18,19