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Furthermore, HUC-MSC-exosome therapy reduces inflammatory response through decreasing F4/80 + and CD11c + macrophages and the levels of tumor necrosis factor-alpha (TNF-) and Interleukins-6 (IL-6) (179)

It is certain that while B1 cells from the spleen did not die of iron during GPX4 deficiency, B1 cells taken from the abdominal cavity of mice experienced a higher degree of ferroptosis at the time of GPX4 defect (166) ( Figure 3 )

Gastric bypass and ileal resection surgeries : B12 deficiencies are common after these surgeries, in part because the procedures remove or bypass B12 absorption sites in the gut