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64 GiacobiniP.MessinaA.WrayS.GiampietroC.CrepaldiT.CarmelietP.et al (2007)

IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns

These progenitors exhibit pro-fibrotic and pro-inflammatory differentiation trajectories in response to joint injury

(3) GSH biosynthesis in yeast is tightly controlled via a feedback repression mechanism [30