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A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern

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Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27(Kip1) signaling axis

The plasma NAD(+) metabolome is dysregulated in normal aging

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Ongoing scientific investigations continue to expand knowledge of the molecule and its biochemical characteristics within experimental research environments