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However, RCTs utilize varying restrictive inclusion (e.g., age, disease severity) and exclusion (e.g., comorbidities, concomitant medications) criteria, leading to variabilities between patients in RCTs and those in the real world

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The concentration of the extracted RNA was measured using Namedrops (Denovix, U.S.A) and the QuantiTect reverse transcription kit (Two Step RT-PCR Kit, Qiagen, Germany) was used for cDNA preparation

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