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In one study, the dichloromethane fraction of areca nut was found to inhibit MAO-A isolated from rat brain with a high IC50 value of 665 65.1 g/mL, and produced responses similar to those of the selective pharmacological inhibitor of MAO-A, moclobemide, in pharmacological models of depression, though the direct inhibitory effects of areca alkaloids on MAO-A activity were not observed ( MAO-A may shed light on the mechanism of BQ addiction and aid in the discovery of putative biomarkers for the diagnosis and evaluation of BQ addiction (Hung et al., 2024), as well as help in the design of MAO inhibitors which may aid in the pharmacological management of BQ addiction