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Samples were excited using a 40-MHz pulse tuned to 488 nm for both intensity and fluorescence lifetime measurements

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ALT and AST leaking in the culture medium were determined using Roche Cobas Automatic Biochemical Analyzer (Basel, Switzerland)

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Placebo (FOURIER trial, N=27,564) Monitoring recommended / fasting lipid panel every 4 to 12 weeks after initiation Prescriber disclosure / always required for any new supplement How Repatha (Evolocumab) Works and Why Metabolism Matters Evolocumab is a fully human IgG2 monoclonal antibody that binds proprotein convertase subtilisin/kexin type 9 (PCSK9), blocking PCSK9 from degrading LDL receptors on hepatocytes