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[18] Systemic side effects may include headache, irritability, restlessness, depression, fatigue, or edema resulting from fluid retention

This state may be secondary to a persisting stressor, such as a redox imbalance (251), persistent infection (201, 251), injury (201), insufficient nutrients (201), cold temperatures (201), or it could be due to a defect in the switch that turns off this protective state (251)

conflicting evidence

Antioxid Redox Signal 22(9):744759 Nobrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM et al (2016) G6PD protects from oxidative damage and improves healthspan in mice

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