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A total pre and post vaping nicotine physical effects score was created by averaging the ratings of the following measures at each time point

E-cigarette device and vaping protocol E-liquids were aerosolized at 3.6 volts using 2.5 bottom coil in an e-cigarette (Innokin iTaste VV4 v4) for 30 puffs (4 s duration each with 60 s inter-puff interval)

In some devices it is possible for e-liquids to come into direct contact with the heating coils in a process known as dripping, which may introduce metals and other constituents into the aerosol that users inhale

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