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Its version without Drug Affinity Complex (DAC) typically has a shorter half-life measured in hours, while the DAC-modified version can remain active for several days because the modification slows degradation since the DAC component allows the peptide to bind to albumin in the bloodstream, extending circulation time

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These crystals create physical shearing forces that can unfold or fragment the peptide chains

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Although it had an overall higher accuracy, it was substantially less sensitive for predicting one month and three month mortality compared to either the MDF or the MELD