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Indeed, macrocytosis is a marker for alcohol abuse

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Neurological symptoms can include tingling or numbness in the hands and feet (peripheral neuropathy), a sensation often described as "pins and needles"

Many studies have found that reflux does not directly damage the esophageal epithelium, but stimulates the secretion of inflammatory chemokines by the epithelial cells, which induces proliferative changes in the epithelium and recruitment of inflammatory cells such as T lymphocytes, which in turn leads to the damage of the esophageal epithelium

At least for metformin it can be expected that current clinical trials will catch upon this