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The consistency of safety findings across these independent trials enhances confidence in the conclusions
These findings align well with our correlation analyses, in which butyrate levels positively correlated with muscle mass and function, while showing negative associations with the oxidative stress marker MDA and atrophy markers Atrogin-1 and MuRF-1
There were inhibited mRNA of inflammatory mediators (iNOS, IL-6, IFN and TNF-), increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [30]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Knezevic M., Gojkovic S., Krezic I., Zizek H., Vranes H., Malekinusic D., Vrdoljak B., Knezevic T., Pavlov K.H., Drmic D., et al
