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Biomolecules 10 , 31 (2019)

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With regards to NRF2-dependent regulation of mitochondrial metabolism, the mRNA levels of carnitine palmitoyl transferase 1A and 2A (CPT1/2), which catalyze the rate limiting step of fatty acid oxidation, are decreased in NRF2 knockout cell lines and mice (Meakin et al., 2014

The distinct microbiome profile of 5A-1MQ-treated mice was also supported by k-means clustering