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Some microbiota-derived signals promote autophagy: butyrate can induce autophagy in neurons and glia by inhibiting HDACs and activating pro-autophagic genes [98]

Multiple clinical trials have established dosing ranges and administration protocols that optimize metabolic benefits while maintaining excellent safety profiles

However, it's more common for patients to observe noticeable changes after completing a full dosage cycle, which typically spans 6 to 12 weeks