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The function of this regulation is to allow rapid response to oxidative challenge by increasing the formation of glutathione, a process dependent on cysteine availability (Figure 2)

Notably, both in-vivo and ex-vivo data showed that GSNO strengthened the outer blood-retinal barrier during endophthalmitis

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doi:10.1097/ALN.0b013e31829761e3 [7] Peeters, MA, Lejeune, J