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Co-crystal structure of 7b in complex with KRAS G13C mutant To further characterize the novel nucleotides with the cyclic linkers, KRAS G13C was co-crystallized with compound 7b to obtain detailed structural insights into ligand binding within the binding pocket (resolution:1.85 , R work : 18.98, R free : 22.78

Michielan A, DInc R

Nie K, Cai M

Under moderate oxidative stress, Keap1 is inhibited, allowing Nrf2 to be translocated to the nucleus, where it acts as an antioxidant