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The study characterized the degradation kinetics of AOD9604 in biological matrices and identified the specific cleavage products generated by endogenous proteases

A limitation of this analysis is that per registry inclusion criteria, patients could have started or switched to a biologic therapy within 12 months prior to the enrollment date

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Metabolism of cisplatin to a nephrotoxin in proximal tubule cells

Rarely, cirrhosis can also lead to hepatocerebral degeneration with encephalopathy which can present with apathy, lethargy, somnolence, and/or extrapyramidal symptoms