While glutathione is generally well-tolerated, the effects of excessive supplementation are not yet fully understood, and specific individuals may experience adverse effects
LCS3 can non-competitively inhibit disulfide bond reductase activity with the IC 50 values of 3.3 M and 3.8 M for the mediated GSR and TXNRD1 inhibitory activities, respectively
AI and AI-assisted tools statement During the preparation of this manuscript, the AI tool ChatGPT (GPT-5, released 2025-08-07) was used to generate Figure 1 and the Graphical Abstract and to improve the readability and language of the manuscript
If storage is sub-optimal (room temperature, high humidity, light exposure), expect significantly shorter viability (perhaps only several months for powder, or days for solution)
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