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Subsequently, a stimulating effect of IGF-1 on collagen tissue in human tendon tissue is supported by in vivo studies, which have demonstrated that local administration of IGF-1 (1 mg) directly induced an elevation in collagen synthesis in human tendon tissue (Nielsen et al., 2024)

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Riegman M, Sagie L, Galed C, et al

The disorder runs the spectrum from subclinical hyperthyroidism to thyrotoxicosis, a life-threatening event