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We can't stress this enough: the storage guidelines for an unopened vial and an opened vial are completely different

Hormonal conditions can be tricky to find and complicated to treat

More clinical research should investigate the effectiveness across different patient conditions, but the existing evidence suggests the treatments are generally safe, well tolerated, and worth trying for those struggling with chronic pain or steroid side effects

doi:10.1067/mpd.2001.112160

Your doctor must ensure your B12 levels are checked before or during treatment

One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation