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We then conducted co-immunoprecipitation experiments from lysates of cells co-expressing TMEM55B-eGFP with individual HA-tagged TBC1D9B-domains (C-terminus (aa 8101250), N-terminus (aa 1450), TBC-domain (aa 450810), TBC + EF-hand domain (aa 450950), TBC + GRAM domain (aa 301810)) (Fig

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These findings suggest a substantial degree of central sensitization in cirrhosis, highlighting nociplastic pain as a crucial component of chronic pain in these patients (68, 81)

In a 12-week randomized clinical trial involving 300 obese adults, participants receiving 1 mg daily of AOD-9604 lost an average of 2.6 kg (approximately 5.7 pounds) compared to 0.8 kg (1.8 pounds) in the placebo group

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