Similar to the alterations that occur in metabolic programs in SDH-deficient cancers, FH-deficient cells exhibit a substantial metabolic reorganization
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In a previous Phase I trial, six patients treated with a single dose of NTLA-2001 showed significant reductions in serum TTR protein levels, with no serious adverse effects or liver damage reported
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Clinically, systemic hypothermia is intentionally induced during cardiac surgery or organ transplantation (11, 12), and immune cells stored under hypothermic conditions may re-enter the circulation following transplantation (13)