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Meanwhile, the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate participate in Ca 2+ signaling at postsynaptic neurons [93, 94]

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[] It plays an essential role in the physiological and pathological processes of various diseases, such as diabetes, hyperlipidemia, and CVD

338 The accumulation of ROS further exacerbates cellular stress by inducing genotoxic damage, which can lead to overactivation of the p53 tumor suppressor gene, driving persistent senescence and amplifying inflammatory signaling through increased cytokine and metalloproteinase production, potentially accelerating the onset or progression of RA and other age-related inflammatory conditions