In studies, injections of certain prescription medications reduced obese participants body weight by up to 30%, but it took 72 weeks for that amount of weight loss to happen
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doi: 10.2337/diab.35.3.282
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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
Such guidelines would help researchers find optimal dosages based on research objectives, desired outcomes, and the characteristics of the experiment