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doi: 10.1523/jneurosci.4507-10.2011 65 MisraDP

The reduction of these disulfide bonds results in oxidation of thioredoxin which then is reduced by thioredoxin reductase

Reduction in the activity of genes such as the one that regulates the enzyme methyl-enetetrahydrofolate reductase (MTHFR) increases mean homocysteine levels