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Once patients reached the maintenance dose, GI side effects largely resolved

Excessive beta-glucuronidase activity increases estrogen reabsorption by freeing more conjugated estrogen, which raises circulating estrogen and creates dominance symptoms

Ulin M, Cetin E, Hobeika E, et al

In multiple studies, statins have been shown to decrease ROCK activity in patients with cardiac diseases, such as atherosclerosis, congestive heart failure, hypertension, coronary artery disease, and others (Liu et al., 2009

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Head Neck Surg