Conversely, achieving this within the framework of SSc is, for the most part, not feasible
These unquenched free radicals then turn inward, attacking the mitochondria themselvesdamaging mitochondrial DNA, essential transport proteins, and inner-membrane lipids like cardiolipin
Controlling systemic inflammation is non-negotiable for skin remodeling because chronic low-grade inflammation constantly degrades the extracellular matrix (ECM) faster than any peptide can rebuild it
Veg Sci 50(2):261273 Soares GSF, Assreuy AMS, Gadelha CAA, Gomes VM, Delatorre P, Simes RC, Cavada BS, Leite JF, Nagano CS, Pinto NV, Pessoa HLF, Santi-Gadelha T (2012) Purification and biological activities of Abelmoschus esculentus seed lectin
Heidari R, Ghanbarinejad V, Ommati MM, Jamshidzadeh A, Niknahad H (2018) Mitochondria protecting amino acids: application against a wide range of mitochondria-linked complications
As a representative molecule of NAMPs/DAMPs/PAMPs, the nuclear protein high-mobility group box protein 1 (HMGB1) plays an important role in CNS-related pathologies by being released from damaged cells 24
