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Both primary (to reduce exposure) and secondary (to alter metabolism and deposition) interventions can use specific biomarkers as endpoints of efficacy

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NAMPT-null mice have diminished NAD + synthesis and no other NAD biosynthetic enzymes

D., Bradley, K

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2+ ] i , iNOS, and COX 2 activation, as well as production of NO, underpin the Panx1 channel-dependent release of ATP in LPS-stimulated microglia (Orellana et al., 2013), whereas NO-mediated Cx43 s-nitrosylation is pivotal in the activation of astroglial hemichannels triggered by oxidative stress (Retamal et al., 2006)