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48 Neurodegenerative diseases, for example, Huntingtons disease (HD), Parkinsons disease (PD), and Alzheimers disease (AD), and autism are all associated with iron overload in the developing cerebrum regions

Activation of the NMDAR causes the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase to produce superoxide, which conducts signal transduction between neurons

doi: 10.1001/jamanetworkopen.2023.5626 52 IsraelABerkovitchMMerzonEGolan-CohenAGreenIRuppinEet al

Recently studies have reported the role of iron accumulation and ferroptosis in bone loss

It should be noted that both symptombased prevalence estimates of Alzheimer's dementia and biomarkerbased prevalence estimates of Alzheimer's disease are expected to increase in the future due to growth in the population of Americans age 65 and older, the group most at risk for developing cognitive symptoms

Discussion This study implicates GDH2 and GDH3 gene knockout mutagenesis, metabolomics, and isotope labelling approaches to elucidate how the fungus C