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Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for IgG cleavage due to exosite binding

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These findings support the notion that mitochondrial amino acid metabolic pathways, particularly those involving redox-active substrates such as proline, may serve as auxiliary regulators of ferroptosis, operating alongside canonical CoQ 10 -handling enzymes such as FSP1 or SQOR